Opening book details…
Can I read Differential effects of mu‐ and delta‐receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices on EtoBox?
Differential effects of mu‐ and delta‐receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices by Carl R. Lupica; Thomas V. Dunwiddie is a Neuroscience article available to read on EtoBox.
What is Differential effects of mu‐ and delta‐receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices about?
Previous studies have suggested that opioid receptor activation in the hippocampus increases pyramidal neuron excitability by reducing GABAergic inhibition. This hypothesis has received support with regard to preceptor agonists but has not been adequately tested with selective 6-receptor agonists. In the present investigation we compared the effects of the selective popioid receptor agonist [Tyr-(D-Ala)-Gly-(N-Me-Phe)-Gly-011-enkephalin (DAGO) and the &receptor agonist [D-Pen2,D-Pen5]-enkephalin (DPDPE) to those of bicuculline methiodide (BMI) on extracellularly recorded feedforward (FFW) and recurrent (feedback; FB) inhibition. It was discovered that the control population spike response, evoked by Schaffer collateraVcommissura1 axon stimulation, increased in response to DAGO, DPDPE, and BMI, while the secondary or test response increased only in the presence of DAGO and BMI. The resulting hypothesis that 6-opioid receptor activation facilitates synaptically evoked responses independently of a reduction of inhibition was investigated by examining the effect of DPDPE on the field EPSP response recorded in stratum radiatum of CA1, or postsynaptically on a burst response activated th
Who reads Differential effects of mu‐ and delta‐receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Carl R. Lupica; Thomas V. Dunwiddie
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 1991
- Language
- EN
- Field
- Neuroscience (Life Sciences)