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Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus by Heather R Carstensen; Reinard M Villalon; Navonil Banerjee; Elissa A Hallem; Ray L Hong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Developmental and behavioral plasticity allow animals to prioritize alternative genetic programs during fluctuating environments. Behavioral remodeling may be acute in animals that interact with host organisms, since reproductive adults and the developmentally arrested larvae often have different ethological needs for chemical stimuli. To understand the genes that coordinate the development and host-seeking behavior, we used the entomophilic nematode Pristionchus pacificus to characterize dauer-constitutive mutants (Daf-c) that inappropriately enter developmental diapause to become dauer larvae. We found two Daf-c loci with dauer-constitutive and cuticle exsheathment phenotypes that can be rescued by the feeding of Δ7-dafachronic acid, and that are dependent on the conserved canonical steroid hormone receptor Ppa-DAF-12. Specifically at one locus, deletions in the sole hydroxysteroid dehydrogenase (HSD) in P. pacificus resulted in Daf-c phenotypes. Ppa-hsd-2 is expressed in the canal-associated neurons (CANs) and excretory cells whose homologous cells in Caenorhabditis elegans are not known to be involved in the dauer decision. While in wildtype only dauer larvae are at
Who reads Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Heather R Carstensen; Reinard M Villalon; Navonil Banerjee; Elissa A Hallem; Ray L Hong
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)