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Thymosin Alpha 1 Attenuates Lipid Peroxidation and Improves Fructose-induced Steatohepatitis in Rats by Ferah Armutcu; Ömer Coskun; Ahmet Gürel; Mehmet Kanter; Murat Can; Fatma Ucar; Murat Unalacak is a Medicine article available to read on EtoBox.

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## Objectives: The aim of this study was to investigate the effects of thymosin alpha(1) (talpha(1)) in rats having fructose-induced steatosis. fructose leads to experimental steatosis in the liver by exerting its effect on some components of the oxidant/antioxidant system, and on several cytokines (interleukin-1beta, -2, and -6) in blood. ## Methods: Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (c), which received a purified diet; the high-fructose-fed group (f); and the high-fructose-fed and talpha(1) injected group (f + t). after the experimental period of 10 days, liver lipid peroxidation and antioxidant status, and blood il-1beta, il-2, and il-6 levels were quantified. ## Results: In comparison with the c group, the f group had a higher nitric oxide (no) level, xanthine oxidase (xo) activity, and lipid peroxidation, as indicated by concentrations of thiobarbituric acid reactive substances (tbars), and lower superoxide dismutase (sod) and glutathione peroxidase (gsh-px) activities in the liver. in the f + t group, these markers were near the values of the control group. in addition, increased il-1beta and il-

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Author

Ferah Armutcu; Ömer Coskun; Ahmet Gürel; Mehmet Kanter; Murat Can; Fatma Ucar; Murat Unalacak

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2005

Language

EN

Field

Medicine (Health Sciences)