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This review article examines the correlation between Alzheimer disease (AD) neuropathologic changes, such as amyloid plaques and neurofibrillary tangles, and cognitive status in elderly individuals. It highlights the challenges and biases present in clinicopathologic correlation studies, emphasizing the complexity of understanding cognitive impairment in the context of AD. The authors conclude that while there is strong evidence linking specific neuropathologic features to cognitive decline, many variables

Author

Daniel Quiroga

Language

EN