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Serotonergic Regulation of Somatosensory Cortical Development: Lessons from Genetic Mouse Models by Xiaoyan Luo; Antonio M. Persico; Jean M. Lauder is a Neuroscience article available to read on EtoBox.

What is Serotonergic Regulation of Somatosensory Cortical Development: Lessons from Genetic Mouse Models about?

Monoaminergic neurotransmitter systems appear early during embryogenesis, suggesting that they could play important roles in brain development. Accumulated evidence indicates that serotonin (5-hydroxytryptamine, 5-HT) regulates neural as well as nonneural development, including early aspects of embryonic development, differentiation of neuronal progenitors, and morphogenesis of the craniofacial region, heart and limb. Recent studies using monoamine oxidase-A (MAO-A), 5-HT transporter, vesicular monoamine transporter-2 (VMAT2) and 5-HT~1B~ receptor single, double and triple knockout mice have provided evidence that the serotonergic system plays important roles in barrel field formation in the developing somatosensory cortex. Here we review evidence from these genetic mouse models and, based on the accumulated evidence, propose a testable model for future studies of mechanisms underlying serotonergic regulation of cortical development.

Who reads Serotonergic Regulation of Somatosensory Cortical Development: Lessons from Genetic Mouse Models?

Author

Xiaoyan Luo; Antonio M. Persico; Jean M. Lauder

Publisher

S. Karger AG

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)