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HLA polymorphism in six ethnic groups from Pakistan by A. Mohyuddin; Q. Ayub; S. Khaliq; A. Mansoor; K. Mazhar; S. Rehman; S.Q. Mehdi is a Immunology and Microbiology article available to read on EtoBox.

What is HLA polymorphism in six ethnic groups from Pakistan about?

**Abstract:** The extreme polymorphism found at some of the loci of the HLA system has made it an invaluable tool for population genetic analyses. In this study the genetic polymorphism of six Pakistani ethnic groups was investigated at the HLA‐A, ‐B, ‐C, ‐DRB and DQB1 loci using polymerase chain reaction with sequence specific primers. The groups included in this study are the Baloch, Brahui and Sindhi from the south and the Burusho, Kalash and Pathan from the north of Pakistan. The allele frequencies, three‐locus haplotype frequencies for HLA‐A, ‐C, ‐B and HLA‐A, ‐B, ‐DRB1 are given. Variation in the allele and haplotype distribution between the six Pakistani ethnic groups was observed. A phylogenetic tree and correspondence analysis based on HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele frequencies revealed the Kalash population to be distinct from the remaining Pakistani populations. The Baloch and Brahui were closely related to one another. The Sindhi were closer to the Pathan and Burusho populations than to the neighboring Baloch and Brahui populations, indicating admixture between the northern and southern populations of Pakistan. A phylogenetic tree and correspondence analysis comp

Who reads HLA polymorphism in six ethnic groups from Pakistan?

Author

A. Mohyuddin; Q. Ayub; S. Khaliq; A. Mansoor; K. Mazhar; S. Rehman; S.Q. Mehdi

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-2815)

Published

2002

Language

EN

Field

Immunology and Microbiology (Life Sciences)