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This study investigates the dissolution and phase behavior of amorphous solid dispersions (ASDs) of atazanavir and posaconazole in human intestinal fluids, highlighting their potential to enhance oral bioavailability of poorly soluble drugs. The findings demonstrate that atazanavir ASDs achieve complete release and maintain high flux, while posaconazole shows initial high concentrations that decrease due to crystallization. The research emphasizes the importance of using aspirated human intestinal fluids to

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yitifa4596

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EN