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Gas Chromatography and Titrimetry for the Analysis of Certain Medicinal Amines in Aerosols by Gregory B. Lawless; John J. Sciarra; Anthony J. Monte-Bovi is a Chemistry article available to read on EtoBox.

What is Gas Chromatography and Titrimetry for the Analysis of Certain Medicinal Amines in Aerosols about?

A comparison was made of various methods which could be utiIized to determine quantitatively various medicinal amines used in a pressurized dosage form. The medicinal amines investigated during this study were atropine N.F., butacaine, ephedrine (anhydrous) N.F., tuaminoheptane, and propylhexedrine U.S.P. The conditions necessary for the chromatographic analysis were established initially using liquid samples of the medicinal amines dissolved in acetone, nitrobenzene, ethanol, and/or chloroform. Once these conditions were established, the aerosol formulation containing the medicinal amine was analyzed by gas chromatography. A procedure for sampling the aerosol was developed, so that those medicinal aerosol products containing amines also could be analyzed by several existing methods of analysis. A titrimetric method was used for each aerosol as a means of comparison for the gas chromatographic analysis. Atropine and butacaine aerosols could not be determined by gas chromatogra hy. Tuaminoheptane and propylhexedrine were assayed by gas chromatography f)rom a nitrobenzene solution, while e hedrine was assayed from an acetone solution. The results of this investigation in&cate the eff

Who reads Gas Chromatography and Titrimetry for the Analysis of Certain Medicinal Amines in Aerosols?

Author

Gregory B. Lawless; John J. Sciarra; Anthony J. Monte-Bovi

Publisher

John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)

Published

1965

Language

EN

Field

Chemistry (Physical Sciences)