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Feasibility of Selective Cardiac Ventricular Electroporation by Sugrue, Alan; Vaidya, Vaibhav R.; Livia, Christopher; Padmanabhan, Deepak; Abudan, Anas; Isath, Ameesh; Witt, Tyra; DeSimone, Christopher V.; Stalboerger, Paul; Kapa, Suraj; Asirvatham, Samuel J.; McLeod, Christopher J.; Tolkacheva, Elena G. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Feasibility of Selective Cardiac Ventricular Electroporation about?
## Introduction The application of brief high voltage electrical pulses to tissue can lead to an irreversible or reversible electroporation effect in a cell-specific manner. In the management of ventricular arrhythmias, the ability to target different tissue types, specifically cardiac conduction tissue (His-Purkinje System) vs. cardiac myocardium would be advantageous. We hypothesize that pulsed electric fields (PEFs) can be applied safely to the beating heart through a catheter-based approach, and we tested whether the superficial Purkinje cells can be targeted with PEFs without injury to underlying myocardial tissue. ## Methods In an acute (n = 5) and chronic canine model (n = 6), detailed electroanatomical mapping of the left ventricle identified electrical signals from myocardial and overlying Purkinje tissue. Electroporation was effected via percutaneous catheter-based Intracardiac bipolar current delivery in the anesthetized animal. Repeat Intracardiac electrical mapping of the heart was performed at acute and chronic time points; followed by histological analysis to assess effects. ## Results PEF demonstrated an acute dose-dependent functional effect on Purkinje, with titra
Who reads Feasibility of Selective Cardiac Ventricular Electroporation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sugrue, Alan; Vaidya, Vaibhav R.; Livia, Christopher; Padmanabhan, Deepak; Abudan, Anas; Isath, Ameesh; Witt, Tyra; DeSimone, Christopher V.; Stalboerger, Paul; Kapa, Suraj; Asirvatham, Samuel J.; McLeod, Christopher J.; Tolkacheva, Elena G.
- Publisher
- Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)