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Modeling Risk of Hypoglycemia During and Following Physical Activity in People with Type 1 Diabetes Using Explainable Mixed-effects Machine Learning by Clara Mosquera-Lopez; Katrina L. Ramsey; Valentina Roquemen-Echeverri; Peter G. Jacobs is a Medicine article available to read on EtoBox.
What is Modeling Risk of Hypoglycemia During and Following Physical Activity in People with Type 1 Diabetes Using Explainable Mixed-effects Machine Learning about?
Background: Physical activity (PA) can cause increased hypoglycemia (glucose <70 mg/dL) risk in people with type 1 diabetes (T1D). We modeled the probability of hypoglycemia during and up to 24 h following PA and identified key factors associated with hypoglycemia risk. Methods: We leveraged a free-living dataset from Tidepool comprised of glucose measurements, insulin doses, and PA data from 50 individuals with T1D (6448 sessions) for training and validating machine learning models. We also used data from the T1Dexi pilot study that contains glucose management and PA data from 20 individuals with T1D (139 session) for assessing the accuracy of the best performing model on an independent test dataset. We used mixed-effects logistic regression (MELR) and mixed-effects random forest (MERF) to model hypoglycemia risk around PA. We identified risk factors associated with hypoglycemia using odds ratio and partial dependence analysis for the MELR and MERF models, respectively. Prediction accuracy was measured using the area under the receiver operating characteristic curve (AUROC). Results: The analysis identified risk factors significantly associated with hypoglycemia during and followi
Who reads Modeling Risk of Hypoglycemia During and Following Physical Activity in People with Type 1 Diabetes Using Explainable Mixed-effects Machine Learning?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Clara Mosquera-Lopez; Katrina L. Ramsey; Valentina Roquemen-Echeverri; Peter G. Jacobs
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Physical Sciences)