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Can I read Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis on EtoBox?
Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis by Amy M. Gehring; Edward DeMoll; Jacqueline D. Fetherston; Ichiro Mori; George F. Mayhew; Frederick R. Blattner; Christopher T. Walsh; Robert D. Perry is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis about?
## Background: Virulence in the pathogenic bacterium yersinia pestis, causative agent of bubonic plague, has been correlated with the biosynthesis and transport of an iron-chelating siderophore, yersiniabactin, which is induced under iron-starvation conditions. initial dna sequencing suggested that this system is highly conserved among the pathogenic yersinia. yersiniabactin contains a phenolic group and three five-membered thiazole heterocycles that serve as iron ligands. ## Results: The entire y. pestis yersiniabactin region has been sequenced. sequence analysis of yersiniabactin biosynthetic regions (irp2-ybte and ybts) reveals a strategy for siderophore production using a mixed polyketide synthase/nonribosomal peptide synthetase complex formed between hmwp1 and hmwp2 (encoded by irp1 and irp2). the complex contains 16 domains, five of them variants of phosphopantetheine-modified peptidyl carrier protein or acyl carrier protein domains. hmwp1 and hmwp2 also contain methyltransferase and heterocyclization domains. mutating ybts revealed that this gene encodes a protein essential for yersiniabactin synthesis. ## Conclusions: The hmwp1 and hmwp2 domain organization suggests that th
Who reads Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Amy M. Gehring; Edward DeMoll; Jacqueline D. Fetherston; Ichiro Mori; George F. Mayhew; Frederick R. Blattner; Christopher T. Walsh; Robert D. Perry
- Publisher
- Elsevier BV
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)