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One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans by Susanne H. Kirsch; Wolfgang Herrmann; Vera Kruse; Rudolf Eckert; Stefan Gräber; Jürgen Geisel; Rima Obeid is a Medicine article available to read on EtoBox.

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## Background: We aimed to study the effect of long-term supplementation of b-vitamins on folate forms in serum and whole blood (wb) in elderly german subjects. ## Methods: 59 participants (mean age 67 years) were randomized to daily receive either vitamin d3 (1200 iu), folic acid (500 μg), vitamin b12 (500 μg), vitamin b6 (50 mg), and calcium carbonate (456 mg) or vitamin d3 plus calcium carbonate. serum and wb folate forms were measured before and after 6 and 12 months. ## Results: B-vitamins supplementation for 6 months led to higher concentrations of 5-methyltetrahydrofolate (5-methylthf) in serum (mean 49.1 vs. 19.6 nmol/l) and wb (1332 vs. 616 nmol/l). also non-methyl-folate concentrations in serum and wb were higher after 6 months with b-vitamins supplementation. unmetabolized folic acid (ufa) increased after supplementation. thcy concentration was lowered after 1 year of b-vitamin supplementation (mean 13.1 vs. 9.6 μmol/l). a stronger reduction of thcy after 1 year was found in participants who had baseline level >12.5 μmol/l (mean 17.0 vs. 11.9 μmol/l) compared to those with baseline thcy lower than this limit (mean 9.1 vs. 7.4 μmol/l). in contrast, the increases in serum

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Author

Susanne H. Kirsch; Wolfgang Herrmann; Vera Kruse; Rudolf Eckert; Stefan Gräber; Jürgen Geisel; Rima Obeid

Publisher

Walter de Gruyter GmbH

Published

2014

Language

EN

Field

Medicine (Health Sciences)