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A Comparison of Two Radiotherapy Regimens for the Treatment of Symptoms from Advanced Bladder Cancer by V. Srinivasan; C.H. Brown; A.G. Turner is a Medicine article available to read on EtoBox.

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Pain and haematuria are two of the most distressing symptoms in patients with advanced bladder cancer. The aim of palliative radiotherapy is to relieve these symptoms with the minimum of stress to the patient and with minimal side effects. Two treatment regimens were studied: hypofractionated radiotherapy giving 1700 cGy in two fractions over 3 days and conventional palliative radiotherapy giving 4500 cGy in 12 fractions over 26 days. This study assesses 41 patients, all with Grade II-III T3\_4 transitional cell carcinomas of the bladder treated between 1982 and 1989, presenting with haematuria and local pain. Two-fraction (hypofractionated) treatment was given to 22 patients and conventional palliative radiotherapy to 19; patients were selected by performance status. The effect on haematuria was assessed as cleared, intermittent or persistent. Pain was assessed by noting reduction in the need for opiate analgesia. Any side effect was recorded. In the patients receiving two-fraction radiotherapy, 59% had clearance of the haematuria and in 73 % there was improvement of their pain, compared with 16% and 37% respectively in those receiving conventional palliation. Survival of the two

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Author

V. Srinivasan; C.H. Brown; A.G. Turner

Publisher

Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)

Published

1994

Language

EN

Field

Medicine (Health Sciences)