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Selective Head Cooling in Newborn Infants After Perinatal Asphyxia: a Safety Study by Alistair J. Gunn; Peter D. Gluckman; Tania R. Gunn is a Medicine article available to read on EtoBox.

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## Aims: To determine the practicality and safety of head cooling with mild or minimal systemic hypothermia in term neonates with moderate to severe hypoxic-ischemic encephalopathy. ## Methods: Study group infants >/=37 weeks' gestation, who had an umbilical artery ph </=7. 09 or apgars </=6 at 5 minutes, plus evidence of encephalopathy. infants with major congenital abnormalities were excluded. trail design: infants were randomized to either no cooling (controls; rectal temperature = 37.0 +/- 0.2 degreesc, n = 10) or sequentially, either minimal systemic cooling (rectal temperature = 36.3 +/- 0.2 degreesc, n = 6) or mild systemic cooling (rectal temperature = 35.7 +/- 0.2 degreesc, n = 6). head cooling was accomplished by circulating water at 10 degreesc through a coil of tubing wrapped around the head for up to 72 hours. all infants were warmed by servo-controlled overhead heaters to maintain the allocated rectal temperature. the rectal, fontanelle, and nasopharyngeal temperatures were continuously monitored. ## Results: From january 1996 to october 1997, 22 term infants were randomized from 2 to 5 hours after birth. all infants showed a metabolic acidosis at delivery, with simil

Who reads Selective Head Cooling in Newborn Infants After Perinatal Asphyxia: a Safety Study?

Author

Alistair J. Gunn; Peter D. Gluckman; Tania R. Gunn

Publisher

American Academy of Pediatrics (AAP)

Published

1998

Language

EN

Field

Medicine (Health Sciences)