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Insulin-like Growth Factor II in Gynecological Cancers: A Preliminary Study by Subbi P. Mathur; Charles P. Landen; Susan M. Datta; M. Camille Hoffman; Rajesh S. Mathur; Roger C. Young is a Medicine article available to read on EtoBox.

What is Insulin-like Growth Factor II in Gynecological Cancers: A Preliminary Study about?

**PROBLEM:** We have previously reported elevated serum levels of cervical human papilloma viral proteins E6 and E7 and serum insulin‐like growth factor II (IGF‐II) in women with cervical cancer and advanced cervical intraepithelial neoplasia. As most women with cervical cancer have elevated levels of serum IGF‐II, we sought to determine whether the cervical cancer and lymph node biopsies from these women demonstrated increased production of IGF‐II and whether this elevation was also present in ovarian and endometrial cancers. **METHOD OF STUDY:** We used the semi‐quantitative immunofluo‐ rescent antibody assay established in our laboratory to identify the levels of IGF‐II in 21 cervical cancers (seven with matching lymph nodes), 18 benign cervical biopsies, 13 endometrial cancers, 15 benign endometrial biopsies, 5 ovarian cancers, and 15 benign ovarian biopsies. **RESULTS:** The immunofluorescent IGF‐II levels (relative intensity per pixel) were the highest in cervical cancers; they were significantly higher than in matched controls. IGF‐II levels were not higher in ovarian cancers and only slightly elevated in endometrial cancers. The presence of IGF‐II in pelvic lymph nodes of w

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Author

Subbi P. Mathur; Charles P. Landen; Susan M. Datta; M. Camille Hoffman; Rajesh S. Mathur; Roger C. Young

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 8755-8920)

Published

2003

Language

EN

Field

Medicine (Health Sciences)