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Sandmeyer Synthesis of 4-Chloro-DOC by Hofman Hofmann is a document available to read on EtoBox.
What is Sandmeyer Synthesis of 4-Chloro-DOC about?
1) The document describes a multi-step synthesis of the psychedelic drug 4-chloro-2,5-dimethoxyamphetamine (DOC) through a Sandmeyer reaction. 2) Key steps include the reduction of 2,5-dimethoxyphenyl-2-nitropropene to form 2,5-dimethoxyamphetamine, followed by N-acetylation, nitration, reduction to an amine, and chlorination via diazotization. 3) The final product, DOC hydrochloride, is isolated in high purity with a melting point of 188-192°C.
- Author
- Hofman Hofmann
- Language
- EN