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Requirement of CD80 and CD86 Molecules for Antigen Presentation by Eosinophils by N. TAMURA; N. ISHII; M. NAKAZAWA; M. NAGOYA; M. YOSHINARI; T. AMANO; H. NAKAZIMA; M. MINAMI is a Immunology and Microbiology article available to read on EtoBox.

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The authors analysed the antigen‐presenting ability of eosinophils purified from peritoneal exudate cells of interleukin‐5 (IL‐5) transgenic mice. The granulocyte‐macrophage colony‐stimulating factor (GM‐CSF)‐treated eosinophils induced proliferative responses of primed lymph node T cells and thymus T cells to staphylococcal enterotoxin B (SEB), while untreated eosinophils induced little or no response. GM‐CSF‐treated eosinophils also induced proliferation of ovalbumin (OVA)‐primed lymph node T cells to OVA. Although untreated eosinophils expressed no MHC class II molecule on the surface the eosinophils could be induced to express major histocompatibility complex (MHC) class II molecules when treated with GM‐CSF. In the present study, anti‐I‐A^k^ monoclonal antibodies (MoAbs) strongly inhibited proliferation of thymus T cells and proliferation of OVA‐primed lymph node T cells in response to OVA, but weakly inhibited proliferation of primed T cells in response to SEB. Furthermore, CD80 (B7‐1) and CD86 (B7‐2) were expressed on the surfaces of untreated eosinophils. The expression of those two molecules on the eosinophils was increased by incubation with GM‐CSF. Moreover, anti‐CD80 or

Who reads Requirement of CD80 and CD86 Molecules for Antigen Presentation by Eosinophils?

Author

N. TAMURA; N. ISHII; M. NAKAZAWA; M. NAGOYA; M. YOSHINARI; T. AMANO; H. NAKAZIMA; M. MINAMI

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

1996

Language

EN

Field

Immunology and Microbiology (Life Sciences)