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Renal Involvement in Congenital Cytomegalovirus Infection: A Systematic Review by Ríos-Barnés, María (author);Fortuny, Clàudia (author);Alarcón, Ana (author);Noguera-Julian, Antoni (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Renal Involvement in Congenital Cytomegalovirus Infection: A Systematic Review about?

Background: Congenital cytomegalovirus (cCMV) infection is the most frequent mother-to-child transmitted infection worldwide and a prevalent cause of neonatal disease and long-term morbidity. The kidney is a target organ for CMV, which replicates in renal tubules and is excreted in large quantities in urine for years in children with cCMV infection. Nonetheless, kidney disease has rarely been reported in cCMV-infected patients. Objective: We aimed to describe the available data on renal involvement in patients with cCMV infection at the pathologic, functional, anatomical, and/or clinical levels. Methods: A systematic search was performed in the MEDLINE/PubMed, SCOPUS, and Cochrane databases. Studies describing any renal involvement in fetuses or neonates aged ≤3 weeks at diagnosis of microbiologically confirmed cCMV infection were eligible. Results: Twenty-four articles were included, with a very low level of evidence. Pathologic findings in autopsy studies universally described CMV typical inclusion bodies in tubular cells. No functional studies were identified. cCMV infection was not associated with an increased risk of kidney malformations. Congenital nephrotic syndrome was the

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Author

Ríos-Barnés, María (author);Fortuny, Clàudia (author);Alarcón, Ana (author);Noguera-Julian, Antoni (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)