Can I read Detrusor Underactivity Causes Neurogenic Voiding Dysfunction in a Rat Bilateral Accessory Nerve-injury Model on EtoBox?
Detrusor Underactivity Causes Neurogenic Voiding Dysfunction in a Rat Bilateral Accessory Nerve-injury Model by Kotomi Maeda; Yuji Hotta; Ryoya Kawata; Tomoya Kataoka; Kazunori Kimura is a Medicine article available to read on EtoBox.
What is Detrusor Underactivity Causes Neurogenic Voiding Dysfunction in a Rat Bilateral Accessory Nerve-injury Model about?
We aimed to investigate detrusor function in a previously developed rat neurogenic voiding dysfunction model that we have developed previously. We performed sham or bilateral accessory nerve injury (BACNI) surgeries on ten-week-old male Wistar/ST rats. One week after surgery, we evaluated detrusor contractility in the bladder using isometric tension and mRNA expression assays. Cholinergic contraction was attenuated in the injury model, whereas carbachol-evoked contraction was enhanced, and mRNA expression of the cholinergic receptor increased. These findings suggest that there was a reduction in neurotransmitter release causing detrusor underactivity.
Who reads Detrusor Underactivity Causes Neurogenic Voiding Dysfunction in a Rat Bilateral Accessory Nerve-injury Model?
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- Author
- Kotomi Maeda; Yuji Hotta; Ryoya Kawata; Tomoya Kataoka; Kazunori Kimura
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)