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Survival Impact of Occult Liver Metastasis and Peritoneal Dissemination Compared with Radiologically Defined Distant Organ Metastasis in Pancreatic Ductal Adenocarcinoma by Daisuke Hashimoto; Tatsuma Sakaguchi; Sohei Satoi; Tomohisa Yamamoto; So Yamaki; Mitsuaki Ishida; Yuki Matsui; Nobuhiro Shibata; Shogen Boku; Utae Katsushima; Tsukasa Ikeura; Mitsugu Sekimoto is a Medicine article available to read on EtoBox.

What is Survival Impact of Occult Liver Metastasis and Peritoneal Dissemination Compared with Radiologically Defined Distant Organ Metastasis in Pancreatic Ductal Adenocarcinoma about?

Background Characteristics and prognoses of patients with occult metastases (OM) of pancreatic ductal adenocarcinoma (PDAC) compared with radiologically defined metastases (RM) have been rarely reported. Objective We aimed to clarify the prognosis of OM compared with RM and to establish a treatment strategy for PDAC patients with OM. Methods This single-institution, retrospective study evaluated patients with unresectable PDAC between 2008 and 2018. OM was defined as abdominal metastasis that was detected by staging laparoscopy or open laparotomy but not in the initial assessment of radiological images. Results OM and RM were identified in 135 and 112 patients, respectively. Eastern Cooperative Oncology Group Performance Status (ECOG PS), neutrophil to lymphocyte ratio (NLR), tumor diameter, and rate of local unresectability were significantly lower in the OM group. Median overall survival (OS) of OM was significantly better than that of RM (13.0 vs 8.9 months, p < 0.001). In multivariate analysis of OS, ECOG PS ≥ 1 (HR 1.64, p = 0.009), NLR ≥5 (HR 1.97, p = 0.004), carbohydrate antigen (CA) 19–9 ≥1000 (HR 1.68, p = 0.001), tumor diameter ≥40 mm (HR 1.40, p = 0.027), conversion sur

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Author

Daisuke Hashimoto; Tatsuma Sakaguchi; Sohei Satoi; Tomohisa Yamamoto; So Yamaki; Mitsuaki Ishida; Yuki Matsui; Nobuhiro Shibata; Shogen Boku; Utae Katsushima; Tsukasa Ikeura; Mitsugu Sekimoto

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)