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Development and Characterization of a Hydrogel-based Adhesive Patch for Sealing Open-globe Injuries by Clotilde Jumelle; Ann Yung; Ehsan Shirzaei Sani; Yukako Taketani; Fanny Gantin; Louisa Bourel; Shudan Wang; Erdem Yüksel; Senne Seneca; Nasim Annabi; Reza Dana is a Engineering article available to read on EtoBox.
What is Development and Characterization of a Hydrogel-based Adhesive Patch for Sealing Open-globe Injuries about?
Full-thickness wounds to the eye can lead to serious vision impairment. Current standards of care (from suturing to tissue transplantation) usually require highly skilled surgeons and use of an operating theater. In this study, we report the synthesis, optimization, and in vitro and ex vivo testing of photocrosslinkable hydrogel-based adhesive patches that can easily be applied to globe injuries or corneal incisions. According to the type and concentration of polymers used in the adhesive formulations, we were able to finely tune the physical properties of the bioadhesive including viscosity, elastic modulus, extensibility, ultimate tensile strength, adhesion, transparency, water content, degradation time, and swellability. Our in vitro studies showed no sign of cytotoxicity of the hydrogels. Moreover, the hydrogel patches showed higher adhesion on freshly explanted pig eyeballs compared to a marketed ocular sealant. Finally, ex vivo feasibility studies showed that the hydrogel patches could seal complex open-globe injuries such as large incision, cruciform injury, and injury associated with tissue loss. These results suggest that our photocrosslinkable hydrogel patch could represe
Who reads Development and Characterization of a Hydrogel-based Adhesive Patch for Sealing Open-globe Injuries?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Clotilde Jumelle; Ann Yung; Ehsan Shirzaei Sani; Yukako Taketani; Fanny Gantin; Louisa Bourel; Shudan Wang; Erdem Yüksel; Senne Seneca; Nasim Annabi; Reza Dana
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)