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Molecular mechanisms involved in Ras inactivation: the annexin A6–p120GAP complex by Thomas Grewal; Carlos Enrich is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In mammalian cells, a complex network of signaling pathways tightly regulates a variety of cellular processes, such as proliferation and differentiation. New insights from one of the most‐important signaling cascades involved in oncogenesis, the Ras–Raf–MAPK pathway, suggest that the subcellular localisation and assembly of signaling modules of this pathway is crucial to control the biological response. This commonly requires membrane targeting events that are mediated by adaptor/scaffold proteins. Of particular interest is the translocation and complex formation of GTPase‐activating proteins (GAPs), such as p120GAP, at the plasma membrane to inactivate Ras. Recent studies indicate that one member of the annexin family, annexin A6 acts as a targeting protein for p120GAP. This review discusses how annexin A6 modulates the involvement of negative regulators of the Ras–Raf–MAPK pathway contributing to Ras inactivation. BioEssays 28: 1211–1220, 2006. © 2006 Wiley Periodicals, Inc.

Who reads Molecular mechanisms involved in Ras inactivation: the annexin A6–p120GAP complex?

Author

Thomas Grewal; Carlos Enrich

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)