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Tyrosyluria Resulting from Inhibition of p-Hydroxyphenylpyruvic Acid Oxidase in Vitamin C-deficient Guinea Pigs by Vincent G. Zannoni; Bert N. La Du is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Tyrosyluria, the excretion of p-hydrosyphenyl metabolites of tyrosine, such as p-hydroxyphenylpyruvic acid and p-hydrosyphenyllactic acid, occurs after the administration of t.yrosine to scorbutic guinea pigs (1, 2), scorbutic man (3, 4), and to premature infants (5). A persistent tyrosyluria consisting mainly of p-hydroxyphenylpyruvic acid was also present in the unique case of tyrosinosis reported by Medes (6). Earlier studies in t&o have shown that p-hydroxyphenylpyruvic acid oxidase has an unusual susceptibility to inhibition by high concentrations of its substrate (7-9). Recently it has been demonstrated that p-hydroxyphenylpyruvic acid injected intraperitoneally inhibits p-hydroxyphmylpyruvic acid oxidase in scorbutic guinea pigs. In contrast, animals which received adequate amounts of vitamin C were completely protected from this inhibition (10). In view of these findings, it was of interest to determine whether the tyrosyluria subsequent to the feeding of large amounts of tyrosine to vitamin C-deficient animals was due to an inhibition of this oxidase through the formation of the corresponding a-keto acid.

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Author

Vincent G. Zannoni; Bert N. La Du

Publisher

Elsevier BV

Published

1960

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)