Can I read Engineering Choroid Plexus-on-a-chip with Oscillatory Flow for Modeling Brain Metastasis on EtoBox?

Engineering Choroid Plexus-on-a-chip with Oscillatory Flow for Modeling Brain Metastasis by Jungeun Lim; Stephen Rhee; Hyeri Choi; Jungseub Lee; Shruthy Kuttappan; Tri Tho Yves Nguyen; Sunbeen Choi; YongTae Kim; Noo Li Jeon is a Engineering article available to read on EtoBox.

What is Engineering Choroid Plexus-on-a-chip with Oscillatory Flow for Modeling Brain Metastasis about?

The human brain choroid plexus (ChP) is a highly organized secretory tissue with a complex vascular system and epithelial layers in the ventricles of the brain. The ChP is the body's principal source of cerebrospinal fluid (CSF); it also functions as a barrier to separate the blood from CSF, because the movement of CSF through the body is pulsatile in nature. Thus far, it has been challenging to recreate the specialized features and dynamics of the ChP in a physiologically relevant microenvironment. In this study, we recapitulated the ChP structure by developing a microfluidic chip in accordance with established design rules. Furthermore, we used image processing and analysis to mimic CSF flow dynamics within a rlcking system; we also used a hydrogel containing laminin to mimic brain extracellular matrix (ECM). Human ChP cells were cultured in the ChP-on-a-chip with __in vivo__-like CSF dynamic flow and an engineered ECM. The key ChP characteristics of capillaries, the epithelial layer, and secreted components were recreated in the adjusted microenvironment of our human ChP-on-a-chip. The drug screening capabilities of the device were observed through physiologically relevant drug

Who reads Engineering Choroid Plexus-on-a-chip with Oscillatory Flow for Modeling Brain Metastasis?

Author

Jungeun Lim; Stephen Rhee; Hyeri Choi; Jungseub Lee; Shruthy Kuttappan; Tri Tho Yves Nguyen; Sunbeen Choi; YongTae Kim; Noo Li Jeon

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)