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Multiple drugs Disseminated Aspergillus calidoustus infection and lack of efficacy: case report A 40-year-old man developed disseminated Aspergillus calidoustus infection during immunosuppression therapy with prednisone, ruxolitinib and tacrolimus. Additionally, the man exhibited lack of efficacy during treatment with amphotericin B liposomal, isavuconazole, micafungin, terbinafine and voriconazole for disseminated Aspergillus calidoustus infection [not all routes stated].The man presented to a hospital for routine screening. He had Hodgkin's lymphoma and had undergone haematopoietic cell transplantation (HCT) 3 years previously. It was complicated by chronic graft-versus-host disease (GvHD) that required longstanding immunosuppression therapy with ruxolitinib 5mg twice a day, tacrolimus 1mg twice a day and prednisone 10mg daily. His medical history was also significant for cytomegalovirus (CMV) reactivation treated with foscarnet. During routine screening, he was found to have an elevated serum galactomannan at 1.39. At that time, he had been receiving prophylaxis with isavuconazole 372mg once daily. CT of the chest revealed new patchy ground-glass opacities suspicious for fungal

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Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)