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SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster by Johan Waldholm; Zhi Wang; David Brodin; Anu Tyagi; Simei Yu; Ulrich Theopold; Ann Kristin Östlund Farrants; Neus Visa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background The SWI/SNF chromatin remodeling factors have the ability to remodel nucleosomes and play essential roles in key developmental processes. SWI/SNF complexes contain one subunit with ATPase activity, which in __Drosophila melanogaster__ is called Brahma (Brm). The regulatory activities of SWI/SNF have been attributed to its influence on chromatin structure and transcription regulation, but recent observations have revealed that the levels of Brm affect the relative abundances of transcripts that are formed by alternative splicing and/or polyadenylation of the same pre-mRNA. ## Results We have investigated whether the function of Brm in pre-mRNA processing in __Drosophila melanogaster__ is mediated by Brm alone or by the SWI/SNF complex. We have analyzed the effects of depleting individual SWI/SNF subunits on pre-mRNA processing throughout the genome, and we have identified a subset of transcripts that are affected by depletion of the SWI/SNF core subunits Brm, Snr1 or Mor. The fact that depletion of different subunits targets a subset of common transcripts suggests that the SWI/SNF complex is responsible for the effects observed on pre-mRNA processing when knocking down

Who reads SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster?

Author

Johan Waldholm; Zhi Wang; David Brodin; Anu Tyagi; Simei Yu; Ulrich Theopold; Ann Kristin Östlund Farrants; Neus Visa

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2000]-; Springer Science and Business Media LLC (ISSN 1471-2199)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)