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Mustard lung secrets: Long term clinicopathological study following mustard gas exposure by Javad Beheshti; Eugene J. Mark; Hassan Mohammad Hosein Akbaei; Jafar Aslani; Mostafa Ghanei is a Medicine article available to read on EtoBox.

What is Mustard lung secrets: Long term clinicopathological study following mustard gas exposure about?

Considering the undefinite nature of lung pathology in patients exposed to sulfur mustard (SM) many years after exposure, we conducted this study to document and quantify lung disease in this setting. In a cross sectional study, we selected 23 patients exposed to SM gas approximately 14 years ago during the Iran-Iraq war (1980-1988). We studied their clinical history, physical examination, pulmonary function test (PFT), high-resolution computed tomography scan (HRCT) of the chest, bronchoscopy, and bronchoalveolar lavage (BAL) sampling, and transbronchial lung biopsies. Other potential causes of lung disease, including smoking of cigarettes, were excluded. All 23 patients were symptomatic with cough, dyspnea, and/or felt tight in the chest. All of them had significant air trapping in HRCT and a marked increase of residual volume in PFT. The most common inflammatory cell in BAL fluid was neutrophil (88%). Of the 23 cases, there was sufficient tissue for detailed evaluation in 22. Histologically, 11 cases showed airway epithelial injury, and nine of the 14 lung biopsies with alveoli had histopathological changes diagnosable as organizing pneumonia (OP) or bronchiolitis obliterans OP

Who reads Mustard lung secrets: Long term clinicopathological study following mustard gas exposure?

Author

Javad Beheshti; Eugene J. Mark; Hassan Mohammad Hosein Akbaei; Jafar Aslani; Mostafa Ghanei

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0344-0338)

Published

2006

Language

EN

Field

Medicine (Health Sciences)