Can I read Association study between the dopamine D4 receptor gene and schizophrenia on EtoBox?

Association study between the dopamine D4 receptor gene and schizophrenia by Arturas Petronis; Fabio Macciardi; Andrew Athanassiades; Andrew D. Paterson; Massimiliano Verga; Herbert Y. Meltzer; Philip Cola; Janet A. Buchanan; Hubert H. M. Van Tol; James L. Kennedy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Association study between the dopamine D4 receptor gene and schizophrenia about?

The dopamine D4 receptor is of major interest in schizophrenia research due to its high affinity for the atypical neuroleptic clozapine and a high degree of variability in the receptor gene (DRD4). Although several genetic linkage analyses performed on schizophrenia multiplex families from different regions of the world have either excluded or failed to prove that DRD4 is a major genetic factor for the development of schizophrenia, analyses for moderate predisposing effects are still of significant interest. We performed a study examining differences in allele frequencies of 4 different DRD4 polymorphisms in schizophrenia patients and age, sex, and ethnic origin matched controls. None of these 4 polymorphisms showed evidence for genetic association with schizophrenia, although a trend towards excess of the allele with 7 repeats in the (48), bp exon I11 polymorphism was observed. Complexities in the DRD4 genetic investigation and further analytic approaches are discussed.

Who reads Association study between the dopamine D4 receptor gene and schizophrenia?

Author

Arturas Petronis; Fabio Macciardi; Andrew Athanassiades; Andrew D. Paterson; Massimiliano Verga; Herbert Y. Meltzer; Philip Cola; Janet A. Buchanan; Hubert H. M. Van Tol; James L. Kennedy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)