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A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort by Sulggi A Lee; Christopher A Haiman; Noel P Burtt; Loreall C Pooler; Iona Cheng; Laurence N Kolonel; Malcolm C Pike; David Altshuler; Joel N Hirschhorn; Brian E Henderson; Daniel O Stram is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background Studies in animals and humans clearly indicate a role for prolactin (PRL) in breast epithelial proliferation, differentiation, and tumorigenesis. Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk. ## Methods We evaluated genetic variation in the PRL and PRL receptor (PRLR) genes as predictors of plasma PRL levels and breast cancer risk among African-American, Native Hawaiian, Japanese-American, Latina, and White women in the Multiethnic Cohort Study (MEC). We selected single nucleotide polymorphisms (SNPs) from both the public (dbSNP) and private (Celera) databases to construct high density SNP maps that included up to 20 kilobases (kb) upstream of the transcription initiation site and 10 kb downstream of the last exon of each gene, for a total coverage of 59 kb in PRL and 210 kb in PRLR. We genotyped 80 SNPs in PRL and 173 SNPs in PRLR in a multiethnic panel of 349 unaffected subjects to characterize linkage disequilibrium (LD) and haplotype patterns. We sequenced the coding regions of PRL an

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Author

Sulggi A Lee; Christopher A Haiman; Noel P Burtt; Loreall C Pooler; Iona Cheng; Laurence N Kolonel; Malcolm C Pike; David Altshuler; Joel N Hirschhorn; Brian E Henderson; Daniel O Stram

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2350)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)