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Integrating pharmacokinetics and network pharmacology to identify and validate targets of Guben Xiaozhen prescription for the treatment of chronic urticaria by Yayun Wu; Yuanxin Ren; Lijuan Liu; Ya Zhao; Yang Wang; Ruizhi Zhao; Chuanjian Lu is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Ethnopharmacological relevance: Guben xiaozhen prescription (gxp), a prescription of traditional chinese medicine, has been used to treat skin diseases for a long history and achieved satisfactory therapeutic effects. however, its active ingredients and targets remain to be further elucidated. ## Aim of this study: Identify activity ingredients of gxp for the treatment of chronic urticaria (cu) and further validate the efficacy and targets of the selected component. ## Materials and methods: Firstly, the pharmacokinetics of different disassemble groups of gxp was investigated to screen for active ingredients with improved bioavailability. then, shared targets between active ingredients and cu were performed by network pharmacology. finally, the ovalbumin (ova) induced cu model was used to verify the efficacy and targets of the screened active ingredient. ## Results: Pharmacokinetic results showed that, compared with sub-division groups, the maximum concentration (c) and blood concentration-time curve (auc) of eight ingredients, including 6-shogaol, 6-gingerol, calycosin, dictamnine, fraxinellone, schizandrin, cimifugin, and sec-o-glucosylhamaudol were increased in the gxp group.

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Author

Yayun Wu; Yuanxin Ren; Lijuan Liu; Ya Zhao; Yang Wang; Ruizhi Zhao; Chuanjian Lu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)