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Development of A Population PK Model Using NONMEM by ccrr1033 is a document available to read on EtoBox.

This document outlines the development of a population pharmacokinetic (PK) model using NONMEM, detailing the creation of a data file, control stream for the base model, and the process of running NONMEM. It includes steps for interpreting output files, diagnostic plots, and exploring covariate relationships, ultimately leading to a covariate model that improves the fit of the data. The results indicate significant relationships between clearance and creatinine clearance, as well as volume and weight, with

Author

ccrr1033

Language

EN