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Can I read CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis on EtoBox?
CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis by Jing Wu; Zhijun Zhou; Jin Li; Huifang Liu; Huaqi Zhang; Junchang Zhang; Weibin Huang; Yulong He; Shiyu Zhu; Mingyu Huo; Mingyang Liu; Changhua Zhang is a Medicine article available to read on EtoBox.
What is CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis about?
Aims Chemoresistance remains a major challenge in gastric cancer (GC). Chromodomain helicase DNA-binding protein 4 (CHD4) mediated chromatin remodeling plays critical roles in various tumor types, but its role in chemoresistance in GC remains uncharacterized. Methods CHD4 expression was examined by immunohistochemistry and Western blotting. The role of CHD4 on cell proliferation and chemoresistance of GC was examined in vitro and in vivo. Immunoprecipitation and liquid chromatography-mass spectrometry were used to identify CHD4-binding proteins and a proximity ligation assay was used to explore protein-protein interaction. Results Chemoresistance is associated with upregulation of CHD4 in the tumor tissues of GC patients. Overexpression of CHD4 increased chemoresistance and cell proliferation. Knockdown of CHD4 induced cell apoptosis and cell cycle arrest. CHD4 mediates the decrease of the intracellular concentration of cisplatin by inducing drug efflux. Additionally, CHD4 promotes the interaction between ERK1/2 and MEK1/2, resulting in continuous activation of MEK/ERK pathway. Knockdown of CHD4 in GC increased sensitivity to chemotherapy and suppressed tumor growth in a mouse xeno
Who reads CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jing Wu; Zhijun Zhou; Jin Li; Huifang Liu; Huaqi Zhang; Junchang Zhang; Weibin Huang; Yulong He; Shiyu Zhu; Mingyu Huo; Mingyang Liu; Changhua Zhang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)