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Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer’s disease by Qiong-Lan Yuan; Li-Fen Liu; Yu-Tong Liu; Dan-Dan Wu; Jie Cheng; Na-Na Li; Ya-Ni Zheng; Liang Huang is a Neuroscience article available to read on EtoBox.
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## Abstract Extracellular amyloid beta (Aβ) plaques are main pathological feature of Alzheimer’s disease. However, the specific type of neurons that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown. In this study, we found that 5-hydroxytryptamin receptor 3A subunit (HTR3A) was highly expressed in the brain tissue of transgenic amyloid precursor protein and presenilin-1 mice (an Alzheimer’s disease model) and patients with Alzheimer’s disease. To investigate whether HTR3A-positive interneurons are associated with the production of Aβ plaques, we performed double immunostaining and found that HTR3A-positive interneurons were clustered around Aβ plaques in the mouse model. Some amyloid precursor protein-positive or β-site amyloid precursor protein cleaving enzyme-1-positive neurites near Aβ plaques were co-localized with HTR3A interneurons. These results suggest that HTR3A -positive interneurons may partially contribute to the generation of Aβ peptides. We treated 5.0–5.5-month-old model mice with tropisetron, a HTR3 antagonist, for 8 consecutive weeks. We found that the cognitive deficit of mice was partially reversed, Aβ plaques and neuroinflammation were
Who reads Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer’s disease?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Qiong-Lan Yuan; Li-Fen Liu; Yu-Tong Liu; Dan-Dan Wu; Jie Cheng; Na-Na Li; Ya-Ni Zheng; Liang Huang
- Publisher
- Medknow
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)