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Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride by Jia Chen; Ke-Ren Shan; Yi-Guo Long; Ya-Nan Wang; Agneta Nordberg; Zhi-Zhong Guan is a Environmental Science article available to read on EtoBox.

What is Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride about?

In an attempt to elucidate the mechanism by which excessive fluoride damages the central nervous system, the effects of exposure of PC12 cells to different concentrations of fluoride for 48 h on nicotinic acetylcholine receptors (nAChRs) were characterized here. Significant reductions in the number of binding sites for both [3H]epibatidine and [125I]alpha-bungarotoxin, as well as a significant decrease in the B(max) value for the high-affinity of epibatidine binding site were observed in PC12 cells subjected to high levels of fluoride. On the protein level, the alpha 3 and alpha 7 subunits of nAChRs were also significantly decreased in the cells exposed to high concentrations of fluoride. In contrast, such exposure had no significant effect on the level of the beta 2 subunit. These findings suggest that selective decreases in the number of nAChRs may play an important role in the mechanism(s) by which fluoride causes dysfunction of the central nervous system.

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Author

Jia Chen; Ke-Ren Shan; Yi-Guo Long; Ya-Nan Wang; Agneta Nordberg; Zhi-Zhong Guan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2003

Language

EN

Field

Environmental Science (Life Sciences)