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Teduglutide-induced acute gastric mucosal necrosis in short bowel syndrome with hepatorenal failure: Case report by Tohru Takahashi; Taku Maejima; Dai Miyazaki; Susumu Fukahori; Masahiro Hagiwara is a Medicine article available to read on EtoBox.

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## Introduction Short bowel syndrome (SBS) resulting from acute aortic dissection (AAD)-induced visceral malperfusions leads to chronic intestinal failure (CIF), necessitating patients to adopt home parenteral nutrition to prevent malabsorption. Teduglutide (TED), a glucagon-like peptide-2 analog, is a promising pharmacotherapy for intestinal rehabilitation that reduces parenteral support and improves the quality of life. Gastric mucosal necrosis, a rare gastrointestinal disorder, had never been observed as an adverse event relevant to this drug. We report a case of mucosal necrosis in the stomach after TED treatment for SBS-CIF with hepatorenal failure. ## Presentation of case A 68-year-old Japanese man who underwent massive intestinal resection for AAD experienced malnutrition and diarrhea caused by SBS-CIF. The patient received TED to improve intestinal absorption and entero-hepatic circulation besides controlling infectious diseases. Endoscopy showed mucosal hyperplasia in the stomach and duodenum 1.5 months after TED administration. The patient consented to enteral nutrition via a nasogastric tube because of anorexia. The nutritional status gradually improved after initiating

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Author

Tohru Takahashi; Taku Maejima; Dai Miyazaki; Susumu Fukahori; Masahiro Hagiwara

Publisher

Elsevier

Published

2024

Language

EN

Field

Medicine (Health Sciences)