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Profiles of circulating cytokines in patients with Crohn's disease under maintenance therapy with infliximab by Kotaro Ogawa; Takayuki Matsumoto; Motohiro Esaki; Takehiro Torisu; Mitsuo Iida is a Medicine article available to read on EtoBox.

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Background and aims The effects of maintenance infliximab for Crohn's disease vary widely among patients. The aim of this study was to examine the cytokine profiles and to identify possible markers predictive of therapeutic effect of maintenance infliximab. Methods Cytokine profiles of 35 Crohn's disease patients under maintenance infliximab therapy were analyzed prospectively. Blood samples were obtained prior to, and 2 and 6weeks after infliximab infusion. Circulating cytokine values of interleukin (IL)-23, IL-17A, IL-12, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α) were compared according to the disease activity and therapeutic efficacy. Patients were classified into either the active or quiescent phase according to their disease activity at baseline. Patients were also divided into a sustained response group and non-sustained response group according to therapeutic efficacy of infliximab determined 2 and 6weeks after infliximab infusion. Results At baseline, serum levels of IL-23 (p<0.05), IL-17A (p<0.01), IFN-γ (p<0.05), and IL-6 (p<0.01) were significantly higher in active Crohn's disease than in quiescent disease. These cytokine levels remained unc

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Author

Kotaro Ogawa; Takayuki Matsumoto; Motohiro Esaki; Takehiro Torisu; Mitsuo Iida

Publisher

Oxford University Press (OUP)

Published

2012

Language

EN

Field

Medicine (Health Sciences)