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Monocyte Distribution Width as a Diagnostic Marker for Infection by Alexandra Malinovska; Benjamin Hernried; Andrew Lin; Oluwakemi Badaki-Makun; Katherine Fenstermacher; Ann Margret Ervin; Stephan Ehrhardt; Scott Levin; Jeremiah S. Hinson is a Medicine article available to read on EtoBox.

What is Monocyte Distribution Width as a Diagnostic Marker for Infection about?

Background Monocyte distribution width (MDW) is an emerging biomarker for infection. It is available easily and quickly as part of the CBC count, which is performed routinely on hospital admission. The increasing availability and promising results of MDW as a biomarker in sepsis has prompted an expansion of its use to other infectious diseases. Research Question What is the diagnostic performance of MDW across multiple infectious disease outcomes and care settings? Study Design and Methods A systematic review of the diagnostic performance of MDW across multiple infectious disease outcomes was conducted by searching PubMed, Embase, Scopus, and Web of Science through February 4, 2022. Meta-analysis was performed for outcomes with three or more reports identified (sepsis and COVID-19). Diagnostic performance measures were calculated for individual studies with pooled estimates created by linear mixed-effects models. Results We identified 29 studies meeting inclusion criteria. Most examined sepsis (19 studies) and COVID-19 (six studies). Pooled estimates of diagnostic performance for sepsis differed by reference standard (Second vs Third International Consensus Definitions for Sepsis a

Who reads Monocyte Distribution Width as a Diagnostic Marker for Infection?

Author

Alexandra Malinovska; Benjamin Hernried; Andrew Lin; Oluwakemi Badaki-Makun; Katherine Fenstermacher; Ann Margret Ervin; Stephan Ehrhardt; Scott Levin; Jeremiah S. Hinson

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)