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What is NMR Techniques for mAb Characterization about?

The document discusses the use of high-resolution 2D NMR spectroscopy to characterize the higher order structure of monoclonal antibodies (mAbs) at atomic resolution. It demonstrates the effectiveness of these techniques in establishing consistency in protein folding and structural comparability among related drug products. The study concludes that 2D NMR methods can statistically differentiate between various mAb species and validate a domain fragment-based approach for mAb characterization.

Author

sk01092014776

Language

EN