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Specificity of Cardiac Troponins I and T in Renal Disease by Stefan Willging; Frieder Keller; Gerald Steinbach is a Medicine article available to read on EtoBox.

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## Abstract We investigated and compared serum levels of cardiac troponins I(cTnI) and cardiac troponin T (cTnT) in 85 renal patients (chronic renal impairment n = 23, continuous ambulatory peritoneal dialysis n = 20, hemodialysis n = 42). Patients with the following conditions were excluded: myocardial infarction, angina pectoris, liver disease, malignant neoplasms, enforced physical activity, skeletal muscle trauma, myositis, rhabdomyolysis and seizures. Troponin T was measured by the second generation cTnT-ELISA with a cutoff value = 0.1 μg/l. Troponin I was measured by a cTnI immunoassay analyser with a cut-off value = 2.0 μg/l. Additionally, creatine kinase (CK), CK-MB activity, CKMB mass concentration and myoglobin levels were measured. Specificity was determined as the fraction of true-negative cases compared to the total number of false-positive and true-negative cases. Specificity for cTnT was 96 % [78–100] in patients with renal impairment (creatinine > 150 μmol/l), 95 % [75–100] in continuous ambulatory peritoneal dialysis patients, but in hemodialysis patients it was 75 % [53–92] for short-term hemodialysis ( 1 year). There was a weak correlation between cTnT levels an

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Author

Stefan Willging; Frieder Keller; Gerald Steinbach

Publisher

Walter de Gruyter GmbH

Published

1998

Language

EN

Field

Medicine (Health Sciences)