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Adherence and profile of non-persistence in patients treated for osteoporosis—a large-scale, long-term retrospective study in The Netherlands by J. C. Netelenbos; P. P. Geusens; G. Ypma; S. J. E. Buijs is a Medicine article available to read on EtoBox.

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## Summary We analyzed 12-month compliance for all ten oral osteoporosis drugs in the Netherlands by medication possession ratio (MPR ≥ 80%) in 105,506 patients, and persistence in 8,626 starters indicated high MPR (91%), low persistence (43%), and no restart in 78% of the stoppers after 18 months. ## Introduction We studied compliance and persistence for all available oral osteoporosis medications on a national scale in the Netherlands. ## Methods We analyzed the IMS Health’s longitudinal prescription database, which represents 73% of all pharmacies in the Netherlands. Twelve-month compliance was measured by medication possession ratio (MPR) in a cross-sectional cohort of 105,506 patients who received at least three prescriptions. Twelve-month persistence (no gap in refills for >6 months) was measured in all 8,626 consecutive patients starting therapy, with a further follow-up in non-persistent patients during an additional 18 months for evaluation of switching, restart, or definitive stopping oral medication. Multivariate logistic regression analysis was used to analyze the odds ratios (ORs) with 95% confidence intervals (CI) of characteristics of non-persistence. ## Results MPR

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Author

J. C. Netelenbos; P. P. Geusens; G. Ypma; S. J. E. Buijs

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0937-941X)

Published

2010

Language

EN

Field

Medicine (Health Sciences)