Can I read CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist on EtoBox?
CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist by Tetsuo Narumi; Chihiro Ochiai; Kazuhisa Yoshimura; Shigeyoshi Harada; Tomohiro Tanaka; Wataru Nomura; Hiroshi Arai; Taro Ozaki; Nami Ohashi; Shuzo Matsushita; Hirokazu Tamamura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist about?
Small molecules behaving as CD4 mimics were previously reported as HIV-1 entry inhibitors that block the gp120-CD4 interaction and induce a conformational change in gp120, exposing its co-receptor-binding site. A structure-activity relationship (SAR) study of a series of CD4 mimic analogs was conducted to investigate the contribution from the piperidine moiety of CD4 mimic 1 to anti-HIV activity, cytotoxicity, and CD4 mimicry effects on conformational changes of gp120. In addition, several hybrid molecules based on conjugation of a CD4 mimic analog with a selective CXCR4 antagonist were also synthesized and their utility evaluated.
Who reads CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tetsuo Narumi; Chihiro Ochiai; Kazuhisa Yoshimura; Shigeyoshi Harada; Tomohiro Tanaka; Wataru Nomura; Hiroshi Arai; Taro Ozaki; Nami Ohashi; Shuzo Matsushita; Hirokazu Tamamura
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)