Can I read In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment on EtoBox?
In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment by Irene L. Ibañez; Fernando F. Muñoz; Jorge Zoppi; Ricardo A. Abaurrea; Eduardo A. Scandogliero; Hebe Durán; María Gabriela Guevara is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment about?
Solanum tuberosum aspartic Proteases (StAPs) show selective plasma membrane permeabilization, inducing cytotoxicity of cancer cells versus normal cells in vitro. Herein, we aimed to evaluate both StAP3 systemic toxicity and antitumoral activity against human melanoma in vivo. The toxicity of a single high dose of StAP3 (10 μg/g body weight, intraperitoneally) was assessed in a Balb/c mice model. Subcutaneous A375 human melanoma xenografts in athymic nude (nu/nu) mice were induced. Once tumors developed (mean larger dimension = 3.8 ± 0.09 mm), mice were StAP3-treated (6 μg/g body weight, subcutaneously under the tumor at a single dose). For both models, controls were treated with physiologic saline solution. StAP3-treated mice showed a significant inhibition of tumor growth (p < 0.05) compared with controls. No signs of toxicity were detected in StAP3-treated mice in both models. These results suggest the potential of these plant proteases as anticancer agents.
Who reads In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Irene L. Ibañez; Fernando F. Muñoz; Jorge Zoppi; Ricardo A. Abaurrea; Eduardo A. Scandogliero; Hebe Durán; María Gabriela Guevara
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)