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Cyclooxygenase (COX)-2 as a potent molecular target for prevention and therapy of oral cancer by Masahiro Urade is a Dentistry article available to read on EtoBox.

What is Cyclooxygenase (COX)-2 as a potent molecular target for prevention and therapy of oral cancer about?

Cyclooxygenase (COX)-2 is one of two isoforms of COX that is the rate-limiting enzyme in the production of prostaglandin from arachidonic acid. It is induced by stimuli such as mitogens, cytokines, growth factors and tumor promoters, and has been elucidated to be up-regulated not only at the sites of inflammation but also in various cancer tissues such as colon, stomach, breast, lung and head and neck including oral cavity. Overexpression of COX-2 is known to inhibit apoptosis and immune surveillance, promote angiogenesis, increase cancer invasiveness and metastasis. Therefore, COX-2 is considered to be strongly involved in carcinogenesis and tumor growth. In fact, immunohistochemical and Western blot analyses in oral precancerous and cancerous lesions demonstrated that COX-2 expression is increased from epithelial dysplasia to squamous cell carcinoma through carcinoma in situ, with the elevation of cell proliferating activity. The patients with overexpression of COX-2 showed poor prognosis and their overall 5-year survival rate was decreased. Inhibition of COX-2 activity with selective COX-2 inhibitors or antisense RNA resulted in suppression of tumor cell growth and invasion in v

Who reads Cyclooxygenase (COX)-2 as a potent molecular target for prevention and therapy of oral cancer?

Author

Masahiro Urade

Publisher

Elsevier ; Elsevier BV (ISSN 1882-7616)

Published

2008

Language

EN

Field

Dentistry (Health Sciences)