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Hypermethylation of the GATA gene family in esophageal cancer by MingZhou Guo; Michael G. House; Yoshimitsu Akiyama; Yu Qi; Domenico Capagna; John Harmon; Stephen B. Baylin; Malcolm V. Brock; James G. Herman is a Medicine article available to read on EtoBox.
What is Hypermethylation of the GATA gene family in esophageal cancer about?
## Abstract The GATA family of transcription factors promotes the normal development of the gastrointestinal tract during embryogenesis and determines tissue differentiation in adult gut epithelium. Loss of GATA‐4 and GATA‐5 has been reported in human gastric and colon cancer. We examined GATA‐4,‐5 and ‐6 gene expression in established esophageal squamous cancer cell lines and the relationship to DNA methylation in the promoter region of these genes. GATA‐4 and GATA‐5 expression was absent in most esophageal cancer cell lines, but was restored upon treatment with the demethylating agent 5‐aza‐2′‐deoxycytidine. For each of the cell lines without detectable __GATA__ gene expression, aberrant methylation of the promoter region CpG‐island was detected by methylation specific PCR. We confirmed these results with genomic bisulfite sequencing. GATA‐6 expression was found in each of the cell lines. GATA‐4/‐5 promoter methylation was not detected in normal esophageal mucosa, but GATA‐4 methylation was present in 27 of 44 (61%) squamous carcinomas and 31 of 44 (71%) adenocarcinoma of the esophagus, while GATA‐5 methylation was present in 14 of 44 (32%) squamous carcinomas and 24 of 44 (55%)
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- Author
- MingZhou Guo; Michael G. House; Yoshimitsu Akiyama; Yu Qi; Domenico Capagna; John Harmon; Stephen B. Baylin; Malcolm V. Brock; James G. Herman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)