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Dynamics of cardiac re-entry in micro-CT and serial histological sections based models of mammalian hearts by Ramlugun, Girish S.; Thomas, Belvin; Biktashev, Vadim N.; Fraser, Diane P.; LeGrice, Ian J.; Smaill, Bruce H.; Zhao, Jichao; Biktasheva, Irina V. is a scholarly article available to read on EtoBox.

What is Dynamics of cardiac re-entry in micro-CT and serial histological sections based models of mammalian hearts about?

Cardiac re-entry regime of self-organised abnormal synchronisation underlie dangerous arrhythmias and fatal fibrillation. Recent advances in the theory of dissipative vortices, experimental studies, and anatomically realistic computer simulations, elucidated the role of cardiac re-entry interaction with fine anatomical features in the heart, and anatomy induced drift. The fact that anatomy and structural anisotropy of the heart is consistent within a species suggested its possible functional effect on spontaneous drift of cardiac re-entry. A comparative study of the anatomy induced drift could be used in order to predict evolution of atrial arrhythmia, and improve low-voltage defibrillation protocols and ablation strategies. Here, in micro-CT based model of rat pulmonary vein wall, and in sheep atria models based on high resolution serial histological sections, we demonstrate effects of heart geometry and anisotropy on cardiac re-entry anatomy induced drift, its pinning to fluctuations of thickness in the layer. The data sets of sheep atria and rat pulmonary vein wall are incorporated into the BeatBox High Performance Computing simulation environment. Re-entry is initiated at presc

Author

Ramlugun, Girish S.; Thomas, Belvin; Biktashev, Vadim N.; Fraser, Diane P.; LeGrice, Ian J.; Smaill, Bruce H.; Zhao, Jichao; Biktasheva, Irina V.

Published

2018

Language

EN