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Can I read Impact of MiRNA-181a2 on the Clinical Course of IDH1 Wild Type Glioblastoma on EtoBox?

Impact of MiRNA-181a2 on the Clinical Course of IDH1 Wild Type Glioblastoma by Sippl, Christoph (author);Schoeneberger, Louisa (author);Teping, Fritz (author);Schulz-Schaeffer, Walter (author);Urbschat, Steffi (author);Ketter, Ralf (author);Oertel, Joachim (author) is a Engineering article available to read on EtoBox.

What is Impact of MiRNA-181a2 on the Clinical Course of IDH1 Wild Type Glioblastoma about?

Background: Recently, miRNA-181a2 could be identified as a major regulator of IDH1 expression in fat tissue. The IDH1 gene, its mutation and expression have a major impact on overall survival in patients with glioblastoma. The presented study aimed to investigate the effect of miRNA-181a2 on IDH1 expression in glioblastoma and on the prognosis of patients suffering from, for example, a tumor. Methods: A total of 74 glioblastoma specimens were analyzed for the expression of miRNA-181a2, acquired as fold change, using qRT-PCR. IDH1 protein expression was estimated via mRNA quantification. Eight post mortal, non-glioma related brain tissue specimens served as the control group. The results were correlated with relevant demographic and clinical aspects of the cohort. A TCGA dataset was used as an independent reference. Results: MiRNA-181a2 was significantly downregulated in tumor samples compared to the control group (p < 0.001). In the glioblastoma cohort, 63/74 (85.1%) showed an IDH1 wild type, while 11/74 (14.9%) patients harbored an IDH 1 mutation. In patients with IDH1 wild type glioblastoma, low miRNA-181a2 expression correlated with a prolonged overall survival (p = 0.019), also

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Author
Sippl, Christoph (author);Schoeneberger, Louisa (author);Teping, Fritz (author);Schulz-Schaeffer, Walter (author);Urbschat, Steffi (author);Ketter, Ralf (author);Oertel, Joachim (author)
Publisher
MDPI AG
Published
2021
Language
EN
Field
Engineering (Physical Sciences)

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