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TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow? by T. G. Berryere; S. M. Schmutz; R. J. Schimpf; C. M. Cowan; J. Potter is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Summary Tyrosinase related protein 1 (__TYRP1__), which is involved in the coat colour pathway, was mapped to BTA8 between microsatellites __BL1080__ and __BM4006__, using a microsatellite in intron 5 of __TYRP1__. The complete coding sequence of bovine __TYRP1__ was determined from cDNA derived from skin biopsies of cattle with various colours. Sequence data from exons 2–8 from cattle with diluted phenotypes was compared with that from non‐diluted phenotypes. In addition, full‐sib families of beef cattle generated by embryo transfer and half‐sib families from traditional matings in which coat colour was segregating were used to correlate __TYRP1__ sequence variants with dilute coat colours. Two non‐conservative amino acid changes were detected in Simmental, Charolais and Galloway cattle but these polymorphisms were not associated with diluted shades of black or red, nor with the dun coat colour of Galloway cattle or the taupe brown colour of Braunvieh and Brown Swiss cattle. However, in Dexter cattle all 25 cattle with a dun brown coat colour were homozygous for a H424Y change. One Dexter that was also homozygous Y434 was red because of an ‘E+/E+’ genotype at __MC1R__ which lea

Who reads TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow??

Author

T. G. Berryere; S. M. Schmutz; R. J. Schimpf; C. M. Cowan; J. Potter

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0268-9146)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)