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Some Chemical Effects of Ionizing Radiations on Nucleic Acids and Related Compounds by G. Scholes; J. F. Ward; J. J. Weiss is a Materials Science article available to read on EtoBox.
What is Some Chemical Effects of Ionizing Radiations on Nucleic Acids and Related Compounds about?
## Abstract The degradation of deoxyribonucleic acid (DNA) by irradiation of its aqueous solutions with ionizing radiations in the presence of oxygen has been discussed in terms of the reactions of free radicals (produced by the radiolytic decomposition of the water) with the different molecular entities of the macromolecule. It has been found that attack of the radicals on the purine and pyrimidine bases is a major effect of the irradiation, and it has been estimated that about 80% of the OH radicals attack the base components. In the presence of oxygen an important radiation‐induced reaction is the formation of peroxidic compounds from the pyrimidines. Breakage of the strands in the DNA helix is apparently due mainly to an attack of the radiation‐produced radicals on the sugar moieties which leads to a splitting of the phosphate ester linkages along the chains. The extent of attack which leads to breakage of internucleotide bonds, leading to the production of phosphomonoester groups, has been determined directly: the number of endgroups formed on irradiation with 200 k.v. x‐rays corresponds to a yield of __G__ ⋍ 0.5 (endgroups/100 e.v.). Rupture of hydrogen bonds within the helix
Who reads Some Chemical Effects of Ionizing Radiations on Nucleic Acids and Related Compounds?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- G. Scholes; J. F. Ward; J. J. Weiss
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley (ISSN 0022-3832)
- Published
- 1960
- Language
- EN
- Field
- Materials Science (Physical Sciences)