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Can I read The Evaluation of 2,8-Disubstituted Benzoxazinone Derivatives as Anti-inflammatory and Anti-platelet Aggregation Agents on EtoBox?
The Evaluation of 2,8-Disubstituted Benzoxazinone Derivatives as Anti-inflammatory and Anti-platelet Aggregation Agents by Pei-Wen Hsieh; Tsong-Long Hwang; Chin-Chung Wu; Fang-Rong Chang; Tsai-Wei Wang; Yang-Chang Wu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Evaluation of 2,8-Disubstituted Benzoxazinone Derivatives as Anti-inflammatory and Anti-platelet Aggregation Agents about?
A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2'-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2'-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds 6 and 16 showed inhibitory effects on neutrophil elastase release and superoxide generation.
Who reads The Evaluation of 2,8-Disubstituted Benzoxazinone Derivatives as Anti-inflammatory and Anti-platelet Aggregation Agents?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pei-Wen Hsieh; Tsong-Long Hwang; Chin-Chung Wu; Fang-Rong Chang; Tsai-Wei Wang; Yang-Chang Wu
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)