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Can I read Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose on EtoBox?
Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose by Bruce H Chamberlain; Michelle Rhiner; Neal E Slatkin; Nancy Stambler; Robert J Israel is a Medicine article available to read on EtoBox.
What is Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose about?
## Purpose Opioid-induced constipation (OIC) is a common side effect of opioid therapy. Methylnaltrexone (MNTX) is a selective, peripherally acting μ-opioid receptor antagonist, with demonstrated efficacy in treating OIC. We pooled results from MNTX clinical trials to compare responses to an initial dose in patients with chronic cancer and noncancer pain. ## Patients and Methods This post hoc analysis used pooled data from 3 randomized, placebo-controlled studies of MNTX in patients with advanced illness with OIC. Assessments included the proportions of patients achieving rescue-free laxation (RFL) within 4 and 24 hours of the first study drug dose, time to RFL, current and worst pain intensity, and adverse events, stratified by the presence/absence of cancer. ## Results A total of 355 patients with cancer (MNTX n = 198, placebo n = 157) and 163 without active cancer (MNTX n = 83; placebo n = 80) were included. More patients treated with MNTX compared with those who received placebo achieved an RFL within 4 (cancer: MNTX, 61.1% vs placebo,15.3%, __p__<0.0001; noncancer: MNTX, 62.2% vs placebo, 17.5%, __p__<0.0001) and 24 hours (cancer: MNTX, 71.2% vs placebo, 41.4%, __p__<0.0001; n
Who reads Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose?
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- Author
- Bruce H Chamberlain; Michelle Rhiner; Neal E Slatkin; Nancy Stambler; Robert J Israel
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)